Arrhythmogenic cardiomyopathy (AC) is characterized by fibrofatty infiltration of the right ventricle. ARVC is a genetically determined heart muscle disease that extends across the entire heart. AC accounts for nearly 20% of sudden cardiac death (SCD) cases, being a prominent cause of SCD among young athletes.

Hypertrophic cardiomyopathy (HCM), the most common of the genetic cardiovascular diseases, is characterized by heterogeneous clinical expression, unique pathophysiology and a diverse clinical course. Sudden cardiac death, progressive heart failure, atrial fibrillation and stroke are leading causes of the morbidity and mortality associated with HCM.

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited, highly lethal arrhythmogenic cardiac disorder characterized by ventricular tachycardia in the absence of structural abnormalities of the heart. The mortality rate for untreated patients is 30% to 50% before 35 years of age.

Brugada Syndrome (BrS) is an arrhythmogenic disease characterized by ST-segment elevation on ECG, incomplete right bundle-branch block, and increased risk of sudden cardiac death as the result of ventricular fibrillation. BrS is responsible for 4% of all sudden deaths and 20% of sudden deaths among patients with structurally normal hearts.